Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient’s life expectancy and survival. Unfortunately, there are some issues TKIs are not able...

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Detalles Bibliográficos
Autores principales: Chiarenza, Alessandra, Manetti, Fabrizio, Petricci, Elena, Ruat, Martial, Naldini, Antonella, Taddei, Maurizio, Carraro, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774938/
https://www.ncbi.nlm.nih.gov/pubmed/26934052
http://dx.doi.org/10.1371/journal.pone.0149919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774938/
https://www.ncbi.nlm.nih.gov/pubmed/26934052
http://dx.doi.org/10.1371/journal.pone.0149919

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