Cargando…

Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient’s life expectancy and survival. Unfortunately, there are some issues TKIs are not able...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiarenza, Alessandra, Manetti, Fabrizio, Petricci, Elena, Ruat, Martial, Naldini, Antonella, Taddei, Maurizio, Carraro, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774938/ https://www.ncbi.nlm.nih.gov/pubmed/26934052 http://dx.doi.org/10.1371/journal.pone.0149919

Ejemplares similares

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
por: Pietrobono, Silvia, et al.
Publicado: (2018)

Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe
por: Pietrobono, Silvia, et al.
Publicado: (2018)

Viral targets of acylguanidines
por: Gazina, Elena V., et al.
Publicado: (2012)

Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation
por: Del Giovane, Alice, et al.
Publicado: (2022)

Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway
por: Fleury, Audrey, et al.
Publicado: (2016)

Amino Acylguanidines as Bioinspired Catalysts for the Asymmetric Aldol Reaction
por: Jimeno, Ciril
Publicado: (2021)

A Central Contribution of TG2 Activity to the Antiproliferative and Pro-Apoptotic Effects of Caffeic Acid in K562 Cells of Human Chronic Myeloid Leukemia
por: Feriotto, Giordana, et al.
Publicado: (2022)

Hymeglusin Enhances the Pro-Apoptotic Effects of Venetoclax in Acute Myeloid Leukemia
por: Zhou, Cheng, et al.
Publicado: (2022)

Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities
por: Rayavarapu, Srinuvasarao, et al.
Publicado: (2017)

Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
por: Sioud, Mouldy, et al.
Publicado: (2019)

Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells
por: Navarra, Michele, et al.
Publicado: (2010)

Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells
por: Pisano, Marina, et al.
Publicado: (2007)

Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells
por: Komina, Anna, et al.
Publicado: (2016)

Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells
por: Gatti, Giuliana, et al.
Publicado: (2017)

Antiproliferative effects of L-asparaginase in acute myeloid leukemia
por: Chen, Tingting, et al.
Publicado: (2020)

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
por: Bijlsma, Maarten F, et al.
Publicado: (2006)

Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors
por: Zou, Yiquan, et al.
Publicado: (2013)

LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells
por: Zanelatto, Leonardo Campos, et al.
Publicado: (2016)

Publisher Correction: Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities
por: Rayavarapu, Srinuvasarao, et al.
Publicado: (2020)

Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions
por: Ferent, Julien, et al.
Publicado: (2014)

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations
por: GALIMBERTI, FABRIZIO, et al.
Publicado: (2012)

Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase
por: Nisha, Chaluveelaveedu Murleedharan, et al.
Publicado: (2016)

New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia
por: Hamdy, Ahmed K., et al.
Publicado: (2022)

Antiproliferative and Pro-Apoptotic Effect of Novel Nitro-Substituted Hydroxynaphthanilides on Human Cancer Cell Lines
por: Kauerova, Tereza, et al.
Publicado: (2016)

The Role of Smoothened in Cancer
por: Jeng, Kuo-Shyang, et al.
Publicado: (2020)

Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells
por: Cavalieri, Elisabetta, et al.
Publicado: (2011)

Antiproliferative and apoptotic effects of spanish honeys
por: Morales, Paloma, et al.
Publicado: (2013)

Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma
por: Walden, Daniel, et al.
Publicado: (2017)

AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia
por: Barbetti, V, et al.
Publicado: (2013)

Phytochemical Characterization of Taxus baccata L. Aril with Emphasis on Evaluation of the Antiproliferative and Pro-Apoptotic Activity of Rhodoxanthin
por: Dumitraş, Daria-Antonia, et al.
Publicado: (2022)

New Hybrid Scaffolds Based on 5-FU/Curcumin: Synthesis, Cytotoxic, Antiproliferative and Pro-Apoptotic Effect
por: Moreno-Quintero, Gustavo, et al.
Publicado: (2023)

Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity
por: Peluso, Marisa O., et al.
Publicado: (2014)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
por: Chahal, Kirti Kandhwal, et al.
Publicado: (2019)

The antiproliferative and apoptotic profile of gomesin against DFTD
por: Ikonomopoulou, Maria P., et al.
Publicado: (2018)

Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1
por: Gao, Shan, et al.
Publicado: (2022)

Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
por: Jin, Meihua, et al.
Publicado: (2011)

Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region
por: Birerdinc, Aybike, et al.
Publicado: (2009)

Bromodomain-containing protein 4 is critical for the antiproliferative and pro-apoptotic effects of gambogic acid in anaplastic thyroid cancer
por: Wang, Yonghui, et al.
Publicado: (2018)

8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1
por: Zhang, Qiting, et al.
Publicado: (2021)

Neuroglobin in Breast Cancer Cells: Effect of Hypoxia and Oxidative Stress on Protein Level, Localization, and Anti-Apoptotic Function
por: Fiocchetti, Marco, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oqld4qc50mronjavic31da3l3s