Ranolazine preserves and improves left ventricular ejection fraction and autonomic measures when added to guideline-driven therapy in chronic heart failure

BACKGROUND: Ranolazine (RAN) reduces cardiac sodium channel 1.5’s late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympat...

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Detalles Bibliográficos
Autores principales: Murray, Gary L., Colombo, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wichtig 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774941/
https://www.ncbi.nlm.nih.gov/pubmed/27004101
http://dx.doi.org/10.5301/heartint.5000219

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