Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1

BACKGROUND: Familial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 (KRIT1/CCM1) gene, and characterized by multiple brain lesions. CCM lesions manifest across a range of different phenotypes, including wide differ...

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Detalles Bibliográficos
Autores principales: Choquet, Hélène, Trapani, Eliana, Goitre, Luca, Trabalzini, Lorenza, Akers, Amy, Fontanella, Marco, Hart, Blaine L., Morrison, Leslie A., Pawlikowska, Ludmila, Kim, Helen, Retta, Saverio Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774945/
https://www.ncbi.nlm.nih.gov/pubmed/26795600
http://dx.doi.org/10.1016/j.freeradbiomed.2016.01.008

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