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Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival
BACKGROUND: We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. ME...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774987/ https://www.ncbi.nlm.nih.gov/pubmed/26933963 http://dx.doi.org/10.1371/journal.pone.0150512 |
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author | Chen, Marcelo Wong, Wing-Wai Law, Matthew G. Kiertiburanakul, Sasisopin Yunihastuti, Evy Merati, Tuti Parwati Lim, Poh Lian Chaiwarith, Romanee Phanuphak, Praphan Lee, Man Po Kumarasamy, Nagalingeswaran Saphonn, Vonthanak Ditangco, Rossana Sim, Benedict L. H. Nguyen, Kinh Van Pujari, Sanjay Kamarulzaman, Adeeba Zhang, Fujie Pham, Thuy Thanh Choi, Jun Yong Oka, Shinichi Kantipong, Pacharee Mustafa, Mahiran Ratanasuwan, Winai Durier, Nicolas Chen, Yi-Ming Arthur |
author_facet | Chen, Marcelo Wong, Wing-Wai Law, Matthew G. Kiertiburanakul, Sasisopin Yunihastuti, Evy Merati, Tuti Parwati Lim, Poh Lian Chaiwarith, Romanee Phanuphak, Praphan Lee, Man Po Kumarasamy, Nagalingeswaran Saphonn, Vonthanak Ditangco, Rossana Sim, Benedict L. H. Nguyen, Kinh Van Pujari, Sanjay Kamarulzaman, Adeeba Zhang, Fujie Pham, Thuy Thanh Choi, Jun Yong Oka, Shinichi Kantipong, Pacharee Mustafa, Mahiran Ratanasuwan, Winai Durier, Nicolas Chen, Yi-Ming Arthur |
author_sort | Chen, Marcelo |
collection | PubMed |
description | BACKGROUND: We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. METHODS: Patients testing HBs antigen (Ag) or HCV antibody (Ab) positive within enrollment into TAHOD were considered HBV or HCV co-infected. Factors associated with HBV and/or HCV co-infection were assessed by logistic regression models. Factors associated with post-ART HIV immunological response (CD4 change after six months) and virological response (HIV RNA <400 copies/ml after 12 months) were also determined. Survival was assessed by the Kaplan-Meier method and log rank test. RESULTS: A total of 7,455 subjects were recruited by December 2012. Of patients tested, 591/5656 (10.4%) were HBsAg positive, 794/5215 (15.2%) were HCVAb positive, and 88/4966 (1.8%) were positive for both markers. In multivariate analysis, HCV co-infection, age, route of HIV infection, baseline CD4 count, baseline HIV RNA, and HIV-1 subtype were associated with immunological recovery. Age, route of HIV infection, baseline CD4 count, baseline HIV RNA, ART regimen, prior ART and HIV-1 subtype, but not HBV or HCV co-infection, affected HIV RNA suppression. Risk factors affecting mortality included HCV co-infection, age, CDC stage, baseline CD4 count, baseline HIV RNA and prior mono/dual ART. Shortest survival was seen in subjects who were both HBV- and HCV-positive. CONCLUSION: In this Asian cohort of HIV-infected patients, HCV co-infection, but not HBV co-infection, was associated with lower CD4 cell recovery after ART and increased mortality. |
format | Online Article Text |
id | pubmed-4774987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47749872016-03-10 Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival Chen, Marcelo Wong, Wing-Wai Law, Matthew G. Kiertiburanakul, Sasisopin Yunihastuti, Evy Merati, Tuti Parwati Lim, Poh Lian Chaiwarith, Romanee Phanuphak, Praphan Lee, Man Po Kumarasamy, Nagalingeswaran Saphonn, Vonthanak Ditangco, Rossana Sim, Benedict L. H. Nguyen, Kinh Van Pujari, Sanjay Kamarulzaman, Adeeba Zhang, Fujie Pham, Thuy Thanh Choi, Jun Yong Oka, Shinichi Kantipong, Pacharee Mustafa, Mahiran Ratanasuwan, Winai Durier, Nicolas Chen, Yi-Ming Arthur PLoS One Research Article BACKGROUND: We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. METHODS: Patients testing HBs antigen (Ag) or HCV antibody (Ab) positive within enrollment into TAHOD were considered HBV or HCV co-infected. Factors associated with HBV and/or HCV co-infection were assessed by logistic regression models. Factors associated with post-ART HIV immunological response (CD4 change after six months) and virological response (HIV RNA <400 copies/ml after 12 months) were also determined. Survival was assessed by the Kaplan-Meier method and log rank test. RESULTS: A total of 7,455 subjects were recruited by December 2012. Of patients tested, 591/5656 (10.4%) were HBsAg positive, 794/5215 (15.2%) were HCVAb positive, and 88/4966 (1.8%) were positive for both markers. In multivariate analysis, HCV co-infection, age, route of HIV infection, baseline CD4 count, baseline HIV RNA, and HIV-1 subtype were associated with immunological recovery. Age, route of HIV infection, baseline CD4 count, baseline HIV RNA, ART regimen, prior ART and HIV-1 subtype, but not HBV or HCV co-infection, affected HIV RNA suppression. Risk factors affecting mortality included HCV co-infection, age, CDC stage, baseline CD4 count, baseline HIV RNA and prior mono/dual ART. Shortest survival was seen in subjects who were both HBV- and HCV-positive. CONCLUSION: In this Asian cohort of HIV-infected patients, HCV co-infection, but not HBV co-infection, was associated with lower CD4 cell recovery after ART and increased mortality. Public Library of Science 2016-03-02 /pmc/articles/PMC4774987/ /pubmed/26933963 http://dx.doi.org/10.1371/journal.pone.0150512 Text en © 2016 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chen, Marcelo Wong, Wing-Wai Law, Matthew G. Kiertiburanakul, Sasisopin Yunihastuti, Evy Merati, Tuti Parwati Lim, Poh Lian Chaiwarith, Romanee Phanuphak, Praphan Lee, Man Po Kumarasamy, Nagalingeswaran Saphonn, Vonthanak Ditangco, Rossana Sim, Benedict L. H. Nguyen, Kinh Van Pujari, Sanjay Kamarulzaman, Adeeba Zhang, Fujie Pham, Thuy Thanh Choi, Jun Yong Oka, Shinichi Kantipong, Pacharee Mustafa, Mahiran Ratanasuwan, Winai Durier, Nicolas Chen, Yi-Ming Arthur Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title | Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title_full | Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title_fullStr | Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title_full_unstemmed | Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title_short | Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival |
title_sort | hepatitis b and c co-infection in hiv patients from the treat asia hiv observational database: analysis of risk factors and survival |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774987/ https://www.ncbi.nlm.nih.gov/pubmed/26933963 http://dx.doi.org/10.1371/journal.pone.0150512 |
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