Towards Better Precision Medicine: PacBio Single-Molecule Long Reads Resolve the Interpretation of HIV Drug Resistant Mutation Profiles at Explicit Quasispecies (Haplotype) Level

Development of HIV-1 drug resistance mutations (HDRMs) is one of the major reasons for the clinical failure of antiretroviral therapy. Treatment success rates can be improved by applying personalized anti-HIV regimens based on a patient’s HDRM profile. However, the sensitivity and specificity of the...

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Detalles Bibliográficos
Autores principales: Huang, Da Wei, Raley, Castle, Jiang, Min Kang, Zheng, Xin, Liang, Dun, Rehman, M Tauseef, Highbarger, Helene C., Jiao, Xiaoli, Sherman, Brad, Ma, Liang, Chen, Xiaofeng, Skelly, Thomas, Troyer, Jennifer, Stephens, Robert, Imamichi, Tomozumi, Pau, Alice, Lempicki, Richard A, Tran, Bao, Nissley, Dwight, Lane, H Clifford, Dewar, Robin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775093/
https://www.ncbi.nlm.nih.gov/pubmed/26949565
http://dx.doi.org/10.4172/2153-0602.1000182

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