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An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate au...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775223/ https://www.ncbi.nlm.nih.gov/pubmed/26765567 http://dx.doi.org/10.7554/eLife.10856 |
| _version_ | 1782419028036288512 |
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| author | Dagdas, Yasin F Belhaj, Khaoula Maqbool, Abbas Chaparro-Garcia, Angela Pandey, Pooja Petre, Benjamin Tabassum, Nadra Cruz-Mireles, Neftaly Hughes, Richard K Sklenar, Jan Win, Joe Menke, Frank Findlay, Kim Banfield, Mark J Kamoun, Sophien Bozkurt, Tolga O |
| author_facet | Dagdas, Yasin F Belhaj, Khaoula Maqbool, Abbas Chaparro-Garcia, Angela Pandey, Pooja Petre, Benjamin Tabassum, Nadra Cruz-Mireles, Neftaly Hughes, Richard K Sklenar, Jan Win, Joe Menke, Frank Findlay, Kim Banfield, Mark J Kamoun, Sophien Bozkurt, Tolga O |
| author_sort | Dagdas, Yasin F |
| collection | PubMed |
| description | Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses. DOI: http://dx.doi.org/10.7554/eLife.10856.001 |
| format | Online Article Text |
| id | pubmed-4775223 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47752232016-03-07 An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor Dagdas, Yasin F Belhaj, Khaoula Maqbool, Abbas Chaparro-Garcia, Angela Pandey, Pooja Petre, Benjamin Tabassum, Nadra Cruz-Mireles, Neftaly Hughes, Richard K Sklenar, Jan Win, Joe Menke, Frank Findlay, Kim Banfield, Mark J Kamoun, Sophien Bozkurt, Tolga O eLife Microbiology and Infectious Disease Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses. DOI: http://dx.doi.org/10.7554/eLife.10856.001 eLife Sciences Publications, Ltd 2016-01-14 /pmc/articles/PMC4775223/ /pubmed/26765567 http://dx.doi.org/10.7554/eLife.10856 Text en © 2016, Dagdas et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Microbiology and Infectious Disease Dagdas, Yasin F Belhaj, Khaoula Maqbool, Abbas Chaparro-Garcia, Angela Pandey, Pooja Petre, Benjamin Tabassum, Nadra Cruz-Mireles, Neftaly Hughes, Richard K Sklenar, Jan Win, Joe Menke, Frank Findlay, Kim Banfield, Mark J Kamoun, Sophien Bozkurt, Tolga O An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_full | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_fullStr | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_full_unstemmed | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_short | An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| title_sort | effector of the irish potato famine pathogen antagonizes a host autophagy cargo receptor |
| topic | Microbiology and Infectious Disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775223/ https://www.ncbi.nlm.nih.gov/pubmed/26765567 http://dx.doi.org/10.7554/eLife.10856 |
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