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Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer

The thiamine pyrophosphate (TPP) riboswitch is a cis-regulatory element in mRNA that modifies gene expression in response to TPP concentration. Its specificity is dependent upon conformational changes that take place within its aptamer domain. Here, the role of tertiary interactions in ligand bindin...

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Detalles Bibliográficos
Autores principales:	Duesterberg, Van K, Fischer-Hwang, Irena T, Perez, Christian F, Hogan, Daniel W, Block, Steven M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775224/ https://www.ncbi.nlm.nih.gov/pubmed/26709838 http://dx.doi.org/10.7554/eLife.12362

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