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Multipotent versus differentiated cell fate selection in the developing Drosophila airways
Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located popu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775228/ https://www.ncbi.nlm.nih.gov/pubmed/26633813 http://dx.doi.org/10.7554/eLife.09646 |
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author | Matsuda, Ryo Hosono, Chie Samakovlis, Christos Saigo, Kaoru |
author_facet | Matsuda, Ryo Hosono, Chie Samakovlis, Christos Saigo, Kaoru |
author_sort | Matsuda, Ryo |
collection | PubMed |
description | Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway. DOI: http://dx.doi.org/10.7554/eLife.09646.001 |
format | Online Article Text |
id | pubmed-4775228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47752282016-03-07 Multipotent versus differentiated cell fate selection in the developing Drosophila airways Matsuda, Ryo Hosono, Chie Samakovlis, Christos Saigo, Kaoru eLife Developmental Biology and Stem Cells Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway. DOI: http://dx.doi.org/10.7554/eLife.09646.001 eLife Sciences Publications, Ltd 2015-12-02 /pmc/articles/PMC4775228/ /pubmed/26633813 http://dx.doi.org/10.7554/eLife.09646 Text en © 2015, Matsuda et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology and Stem Cells Matsuda, Ryo Hosono, Chie Samakovlis, Christos Saigo, Kaoru Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title | Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title_full | Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title_fullStr | Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title_full_unstemmed | Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title_short | Multipotent versus differentiated cell fate selection in the developing Drosophila airways |
title_sort | multipotent versus differentiated cell fate selection in the developing drosophila airways |
topic | Developmental Biology and Stem Cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775228/ https://www.ncbi.nlm.nih.gov/pubmed/26633813 http://dx.doi.org/10.7554/eLife.09646 |
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