Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

Large interindividual variability has been observed in the metabolism of CYP2C19 substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 activity, focusing on CYP2C19 diplotypes and the cytochrome P450 oxidoreductase (POR). CYP2C19 gene analysis was carried out on 347...

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Detalles Bibliográficos
Autores principales: Shirasaka, Y, Chaudhry, A S, McDonald, M, Prasad, B, Wong, T, Calamia, J C, Fohner, A, Thornton, T A, Isoherranen, N, Unadkat, J D, Rettie, A E, Schuetz, E G, Thummel, K E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775436/
https://www.ncbi.nlm.nih.gov/pubmed/26323597
http://dx.doi.org/10.1038/tpj.2015.58

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