Cargando…
Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A
Extensive use of zeolite nanoparticles in many areas, including medicine, has led to the concern about an impact and possible risk of their use for human health and the environment. In our studies, we investigated an uptake, retention, and cytotoxicity of nanozeolite A (BaA) functionalized with amin...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775514/ https://www.ncbi.nlm.nih.gov/pubmed/26935303 http://dx.doi.org/10.1186/s11671-016-1334-8 |
_version_ | 1782419041060651008 |
---|---|
author | Męczyńska-Wielgosz, Sylwia Piotrowska, Agata Majkowska-Pilip, Agnieszka Bilewicz, Aleksander Kruszewski, Marcin |
author_facet | Męczyńska-Wielgosz, Sylwia Piotrowska, Agata Majkowska-Pilip, Agnieszka Bilewicz, Aleksander Kruszewski, Marcin |
author_sort | Męczyńska-Wielgosz, Sylwia |
collection | PubMed |
description | Extensive use of zeolite nanoparticles in many areas, including medicine, has led to the concern about an impact and possible risk of their use for human health and the environment. In our studies, we investigated an uptake, retention, and cytotoxicity of nanozeolite A (BaA) functionalized with aminopropyl or poly(ethylene glycol) (PEG) of different chain lengths using human cervical carcinoma cell line. For internalization studies, nanozeolite was labeled with (133)Ba radionuclide. The results show that in the case of PEG modification, toxicity and uptake depend on the PEG chain length. The highest toxicity has been observed for nanozeolites coated with short-length chain (Ba-silane-PEGm(MW350). Also, amine-modified nanozeolites exhibited high toxicity, while nanozeolites coated with long PEG molecules, BaA-silane-PEGm(MW1000), and BaA-silane-PEGm(MW2000), as well as unmodified nanozeolite, seem to be nontoxic. In conclusion, this study shows that uptake, retention, and toxicity of nanozeolites coated with various length PEG molecules groups depend on the molecular weight of PEG. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-016-1334-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4775514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-47755142016-03-22 Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A Męczyńska-Wielgosz, Sylwia Piotrowska, Agata Majkowska-Pilip, Agnieszka Bilewicz, Aleksander Kruszewski, Marcin Nanoscale Res Lett Nano Express Extensive use of zeolite nanoparticles in many areas, including medicine, has led to the concern about an impact and possible risk of their use for human health and the environment. In our studies, we investigated an uptake, retention, and cytotoxicity of nanozeolite A (BaA) functionalized with aminopropyl or poly(ethylene glycol) (PEG) of different chain lengths using human cervical carcinoma cell line. For internalization studies, nanozeolite was labeled with (133)Ba radionuclide. The results show that in the case of PEG modification, toxicity and uptake depend on the PEG chain length. The highest toxicity has been observed for nanozeolites coated with short-length chain (Ba-silane-PEGm(MW350). Also, amine-modified nanozeolites exhibited high toxicity, while nanozeolites coated with long PEG molecules, BaA-silane-PEGm(MW1000), and BaA-silane-PEGm(MW2000), as well as unmodified nanozeolite, seem to be nontoxic. In conclusion, this study shows that uptake, retention, and toxicity of nanozeolites coated with various length PEG molecules groups depend on the molecular weight of PEG. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-016-1334-8) contains supplementary material, which is available to authorized users. Springer US 2016-03-02 /pmc/articles/PMC4775514/ /pubmed/26935303 http://dx.doi.org/10.1186/s11671-016-1334-8 Text en © Męczyńska-Wielgosz et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Nano Express Męczyńska-Wielgosz, Sylwia Piotrowska, Agata Majkowska-Pilip, Agnieszka Bilewicz, Aleksander Kruszewski, Marcin Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title | Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title_full | Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title_fullStr | Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title_full_unstemmed | Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title_short | Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A |
title_sort | effect of surface functionalization on the cellular uptake and toxicity of nanozeolite a |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775514/ https://www.ncbi.nlm.nih.gov/pubmed/26935303 http://dx.doi.org/10.1186/s11671-016-1334-8 |
work_keys_str_mv | AT meczynskawielgoszsylwia effectofsurfacefunctionalizationonthecellularuptakeandtoxicityofnanozeolitea AT piotrowskaagata effectofsurfacefunctionalizationonthecellularuptakeandtoxicityofnanozeolitea AT majkowskapilipagnieszka effectofsurfacefunctionalizationonthecellularuptakeandtoxicityofnanozeolitea AT bilewiczaleksander effectofsurfacefunctionalizationonthecellularuptakeandtoxicityofnanozeolitea AT kruszewskimarcin effectofsurfacefunctionalizationonthecellularuptakeandtoxicityofnanozeolitea |