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Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1

Woad root has been used for the prevention of influenza for hundreds of years in many Asian countries. In this study, the antiviral modes of clemastanin B (CB), epigoitrin, phenylpropanoid portion (PEP), and the mixture of phenylpropanoids, alkaloids, and organic acid portions (PEP + ALK + OA) from...

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Autores principales: Su, Jia-Hang, Diao, Rui-Gang, Lv, Shu-Guang, Mou, Xiao-Dong, Li, Kefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775799/
https://www.ncbi.nlm.nih.gov/pubmed/26989425
http://dx.doi.org/10.1155/2016/2537294
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author Su, Jia-Hang
Diao, Rui-Gang
Lv, Shu-Guang
Mou, Xiao-Dong
Li, Kefeng
author_facet Su, Jia-Hang
Diao, Rui-Gang
Lv, Shu-Guang
Mou, Xiao-Dong
Li, Kefeng
author_sort Su, Jia-Hang
collection PubMed
description Woad root has been used for the prevention of influenza for hundreds of years in many Asian countries. In this study, the antiviral modes of clemastanin B (CB), epigoitrin, phenylpropanoid portion (PEP), and the mixture of phenylpropanoids, alkaloids, and organic acid portions (PEP + ALK + OA) from wood root extract against influenza virus A FM1 were investigated. The results revealed that CB, epigoitrin, PEP, and PEP + ALK + OA exert their anti-influenza activity via inhibiting the virus multiplication, prophylaxis, and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effect on virus attachment and multiplication is the main modes for epigoitrin. All the compounds or chemical portions from woad root extract tested in this study do not have direct virucidal activity. Our results provided the comprehensive analysis of the antiviral mechanism of wood root extract.
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spelling pubmed-47757992016-03-17 Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1 Su, Jia-Hang Diao, Rui-Gang Lv, Shu-Guang Mou, Xiao-Dong Li, Kefeng Evid Based Complement Alternat Med Research Article Woad root has been used for the prevention of influenza for hundreds of years in many Asian countries. In this study, the antiviral modes of clemastanin B (CB), epigoitrin, phenylpropanoid portion (PEP), and the mixture of phenylpropanoids, alkaloids, and organic acid portions (PEP + ALK + OA) from wood root extract against influenza virus A FM1 were investigated. The results revealed that CB, epigoitrin, PEP, and PEP + ALK + OA exert their anti-influenza activity via inhibiting the virus multiplication, prophylaxis, and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effect on virus attachment and multiplication is the main modes for epigoitrin. All the compounds or chemical portions from woad root extract tested in this study do not have direct virucidal activity. Our results provided the comprehensive analysis of the antiviral mechanism of wood root extract. Hindawi Publishing Corporation 2016 2016-02-18 /pmc/articles/PMC4775799/ /pubmed/26989425 http://dx.doi.org/10.1155/2016/2537294 Text en Copyright © 2016 Jia-Hang Su et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Su, Jia-Hang
Diao, Rui-Gang
Lv, Shu-Guang
Mou, Xiao-Dong
Li, Kefeng
Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title_full Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title_fullStr Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title_full_unstemmed Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title_short Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus A FM1
title_sort modes of antiviral action of chemical portions and constituents from woad root extract against influenza virus a fm1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775799/
https://www.ncbi.nlm.nih.gov/pubmed/26989425
http://dx.doi.org/10.1155/2016/2537294
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