Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal

The folate and cobalamin (Cbl-) dependent enzyme methionine synthase (MS) is highly sensitive to oxidation and its activity affects all methylation reactions. Recent studies have revealed alternative splicing of MS mRNA in human brain and patient-derived fibroblasts. Here we show that MS mRNA in SH-...

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Detalles Bibliográficos
Autores principales: Waly, Mostafa, Power-Charnitsky, Verna-Ann, Hodgson, Nathaniel, Sharma, Alok, Audhya, Tapan, Zhang, Yiting, Deth, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775819/
https://www.ncbi.nlm.nih.gov/pubmed/26989453
http://dx.doi.org/10.1155/2016/6143753

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