Cargando…

Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression

Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for abortion, has been reported to have anti-tumor activity in multiple hormone-dependent cancers, including luminal type bre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Rong, Shi, Peiguo, Nie, Zhi, Liang, Huichun, Zhou, Zhongmei, Chen, Wenlin, Chen, Haijun, Dong, Chao, Yang, Runxiang, Liu, Suling, Chen, Ceshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775863/ https://www.ncbi.nlm.nih.gov/pubmed/26941846 http://dx.doi.org/10.7150/thno.14315

Ejemplares similares

Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis
por: Liu, Rong, et al.
Publicado: (2020)

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
por: Shi, Peiguo, et al.
Publicado: (2017)

Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1
por: Liu, Rong, et al.
Publicado: (2018)

The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27(Kip1)
por: Wang, Chunyan, et al.
Publicado: (2015)

Isochromanoindolenines suppress triple-negative breast cancer cell proliferation partially via inhibiting Akt activation
por: Jiang, Xiaoyan, et al.
Publicado: (2021)

Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression
por: Liu, Xue, et al.
Publicado: (2023)

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
por: Qin, Junying, et al.
Publicado: (2015)

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
por: Cui, Qiuxia, et al.
Publicado: (2023)

Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
por: Chen, Chuan-Huizi, et al.
Publicado: (2019)

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
por: Ge, Fei, et al.
Publicado: (2015)

miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5
por: Zhou, Wenhui, et al.
Publicado: (2017)

Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer
por: Kong, Yanjie, et al.
Publicado: (2022)

KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway
por: Kong, Yanjie, et al.
Publicado: (2016)

Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
por: Kong, Yanjie, et al.
Publicado: (2014)

Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor α and Suppresses Human Breast Cancer Cell Proliferation
por: Du, Chengzhi, et al.
Publicado: (2014)

The roles and regulation of the KLF5 transcription factor in cancers
por: Luo, Yao, et al.
Publicado: (2021)

Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2
por: Wang, Danping, et al.
Publicado: (2020)

miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells
por: Liang, Huichun, et al.
Publicado: (2018)

YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway
por: Chen, Zekun, et al.
Publicado: (2017)

Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer
por: Zhao, Ping, et al.
Publicado: (2023)

KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7
por: Kanyomse, Quist, et al.
Publicado: (2022)

Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
por: Fang, Huan, et al.
Publicado: (2023)

TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway
por: Liu, Wenjing, et al.
Publicado: (2020)

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone
por: Zhang, Huijuan, et al.
Publicado: (2016)

Advances in Biomarkers and Endogenous Regulation of Breast Cancer Stem Cells
por: Chen, Wenmin, et al.
Publicado: (2022)

Targeting Breast Cancer Stem Cells
por: Zhang, Lu, et al.
Publicado: (2023)

Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis
por: Liang, Huichun, et al.
Publicado: (2018)

KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8(+) T-cell-dependent antitumor immunity
por: Wu, Qi, et al.
Publicado: (2023)

Development of a novel method for rapid cloning of shRNA vectors, which successfully knocked down CD44 in mesenchymal triple-negative breast cancer cells
por: Zhou, Lei, et al.
Publicado: (2018)

Mifepristone-Induced Hypothyroidism
por: Kalara, Niketa, et al.
Publicado: (2023)

Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
por: Zhou, Wenhui, et al.
Publicado: (2019)

SU6668 suppresses proliferation of triple negative breast cancer cells through down-regulating MTDH expression
por: Wang, Lu, et al.
Publicado: (2013)

Are Basal-Like and Non-Basal-Like Triple-Negative Breast Cancers Really Different?
por: Dogra, Atika, et al.
Publicado: (2020)

Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer
por: Zou, Hailin, et al.
Publicado: (2023)

Are triple-negative tumours and basal-like breast cancer synonymous?
por: Rakha, Emad A, et al.
Publicado: (2007)

Inhibition of LIPG phospholipase activity suppresses tumor formation of human basal-like triple-negative breast cancer
por: Lo, Pang-Kuo, et al.
Publicado: (2020)

Dexamethasone induces docetaxel and cisplatin resistance partially through up-regulating Krüppel-like factor 5 in triple-negative breast cancer
por: Li, Zhen, et al.
Publicado: (2016)

TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression
por: Bi, Jing, et al.
Publicado: (2023)

RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy
por: Liu, Wenjing, et al.
Publicado: (2022)

Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer
por: Wang, Dong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7ed5oag9e72an2n064fr1otuuk