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Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()

To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in Sout...

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Autores principales: Musselwhite, Laura W., Andrade, Bruno B., Ellenberg, Susan S., Tierney, Ann, Belaunzaran-Zamudio, Pablo F., Rupert, Adam, Lederman, Michael M., Sanne, Ian, Sierra Madero, Juan G., Sereti, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776072/
https://www.ncbi.nlm.nih.gov/pubmed/26981576
http://dx.doi.org/10.1016/j.ebiom.2016.01.016
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author Musselwhite, Laura W.
Andrade, Bruno B.
Ellenberg, Susan S.
Tierney, Ann
Belaunzaran-Zamudio, Pablo F.
Rupert, Adam
Lederman, Michael M.
Sanne, Ian
Sierra Madero, Juan G.
Sereti, Irini
author_facet Musselwhite, Laura W.
Andrade, Bruno B.
Ellenberg, Susan S.
Tierney, Ann
Belaunzaran-Zamudio, Pablo F.
Rupert, Adam
Lederman, Michael M.
Sanne, Ian
Sierra Madero, Juan G.
Sereti, Irini
author_sort Musselwhite, Laura W.
collection PubMed
description To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants. Biomarkers were tested for predicting IRIS with adjustment for covariates chosen through forward stepwise selection. Sixty-two participants developed IRIS and of these 19 were tuberculosis (TB)-IRIS. Baseline levels of vitamin D and higher d-dimer, interferon gamma (IFNγ), and sCD14 were independently associated with risk of IRIS in multivariate analyses. TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. Elevated markers of Type 1 T helper (Th1) response, monocyte activation, coagulation and low vitamin D were independently associated with IRIS risk. Interventions that decrease immune activation and increase vitamin D levels warrant further study.
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spelling pubmed-47760722016-03-15 Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study() Musselwhite, Laura W. Andrade, Bruno B. Ellenberg, Susan S. Tierney, Ann Belaunzaran-Zamudio, Pablo F. Rupert, Adam Lederman, Michael M. Sanne, Ian Sierra Madero, Juan G. Sereti, Irini EBioMedicine Research Paper To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants. Biomarkers were tested for predicting IRIS with adjustment for covariates chosen through forward stepwise selection. Sixty-two participants developed IRIS and of these 19 were tuberculosis (TB)-IRIS. Baseline levels of vitamin D and higher d-dimer, interferon gamma (IFNγ), and sCD14 were independently associated with risk of IRIS in multivariate analyses. TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. Elevated markers of Type 1 T helper (Th1) response, monocyte activation, coagulation and low vitamin D were independently associated with IRIS risk. Interventions that decrease immune activation and increase vitamin D levels warrant further study. Elsevier 2016-01-14 /pmc/articles/PMC4776072/ /pubmed/26981576 http://dx.doi.org/10.1016/j.ebiom.2016.01.016 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Musselwhite, Laura W.
Andrade, Bruno B.
Ellenberg, Susan S.
Tierney, Ann
Belaunzaran-Zamudio, Pablo F.
Rupert, Adam
Lederman, Michael M.
Sanne, Ian
Sierra Madero, Juan G.
Sereti, Irini
Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title_full Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title_fullStr Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title_full_unstemmed Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title_short Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study()
title_sort vitamin d, d-dimer, interferon γ, and scd14 levels are independently associated with immune reconstitution inflammatory syndrome: a prospective, international study()
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776072/
https://www.ncbi.nlm.nih.gov/pubmed/26981576
http://dx.doi.org/10.1016/j.ebiom.2016.01.016
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