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The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp.
Recent work from our labs demonstrated that a metabolite(s) from the soil bacterium Streptomyces venezuelae caused dopaminergic neurodegeneration in Caenorhabditis elegans and human neuroblastoma cells. To evaluate the capacity for metabolite production by naturally occurring streptomycetes in Alaba...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776106/ https://www.ncbi.nlm.nih.gov/pubmed/26936423 http://dx.doi.org/10.1038/srep22566 |
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author | Watkins, Anna L. Ray, Arpita R. Roberts, Lindsay Caldwell, Kim A. Olson, Julie B. |
author_facet | Watkins, Anna L. Ray, Arpita R. Roberts, Lindsay Caldwell, Kim A. Olson, Julie B. |
author_sort | Watkins, Anna L. |
collection | PubMed |
description | Recent work from our labs demonstrated that a metabolite(s) from the soil bacterium Streptomyces venezuelae caused dopaminergic neurodegeneration in Caenorhabditis elegans and human neuroblastoma cells. To evaluate the capacity for metabolite production by naturally occurring streptomycetes in Alabama soils, Streptomyces were isolated from soils under different land uses (agriculture, undeveloped, and urban). More isolates were obtained from agricultural than undeveloped soils; there was no significant difference in the number of isolates from urban soils. The genomic diversity of the isolates was extremely high, with only 112 of the 1509 isolates considered clones. A subset was examined for dopaminergic neurodegeneration in the previously established C. elegans model; 28.3% of the tested Streptomyces spp. caused dopaminergic neurons to degenerate. Notably, the Streptomyces spp. isolates from agricultural soils showed more individual neuron damage than isolates from undeveloped or urban soils. These results suggest a common environmental toxicant(s) within the Streptomyces genus that causes dopaminergic neurodegeneration. It could also provide a possible explanation for diseases such as Parkinson’s disease (PD), which is widely accepted to have both genetic and environmental factors. |
format | Online Article Text |
id | pubmed-4776106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47761062016-03-09 The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. Watkins, Anna L. Ray, Arpita R. Roberts, Lindsay Caldwell, Kim A. Olson, Julie B. Sci Rep Article Recent work from our labs demonstrated that a metabolite(s) from the soil bacterium Streptomyces venezuelae caused dopaminergic neurodegeneration in Caenorhabditis elegans and human neuroblastoma cells. To evaluate the capacity for metabolite production by naturally occurring streptomycetes in Alabama soils, Streptomyces were isolated from soils under different land uses (agriculture, undeveloped, and urban). More isolates were obtained from agricultural than undeveloped soils; there was no significant difference in the number of isolates from urban soils. The genomic diversity of the isolates was extremely high, with only 112 of the 1509 isolates considered clones. A subset was examined for dopaminergic neurodegeneration in the previously established C. elegans model; 28.3% of the tested Streptomyces spp. caused dopaminergic neurons to degenerate. Notably, the Streptomyces spp. isolates from agricultural soils showed more individual neuron damage than isolates from undeveloped or urban soils. These results suggest a common environmental toxicant(s) within the Streptomyces genus that causes dopaminergic neurodegeneration. It could also provide a possible explanation for diseases such as Parkinson’s disease (PD), which is widely accepted to have both genetic and environmental factors. Nature Publishing Group 2016-03-03 /pmc/articles/PMC4776106/ /pubmed/26936423 http://dx.doi.org/10.1038/srep22566 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Watkins, Anna L. Ray, Arpita R. Roberts, Lindsay Caldwell, Kim A. Olson, Julie B. The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title | The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title_full | The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title_fullStr | The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title_full_unstemmed | The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title_short | The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. |
title_sort | prevalence and distribution of neurodegenerative compound-producing soil streptomyces spp. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776106/ https://www.ncbi.nlm.nih.gov/pubmed/26936423 http://dx.doi.org/10.1038/srep22566 |
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