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Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction

The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms...

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Detalles Bibliográficos
Autores principales:	Manigrasso, Michaele B., Pan, Jinhong, Rai, Vivek, Zhang, Jinghua, Reverdatto, Sergey, Quadri, Nosirudeen, DeVita, Robert J., Ramasamy, Ravichandran, Shekhtman, Alexander, Schmidt, Ann Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776135/ https://www.ncbi.nlm.nih.gov/pubmed/26936329 http://dx.doi.org/10.1038/srep22450

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