Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail

The chromodomain of HP1α binds directly to lysine 9-methylated histone H3 (H3K9me). This interaction is enhanced by phosphorylation of serine residues in the N-terminal tail of HP1α by unknown mechanism. Here we show that phosphorylation modulates flexibility of HP1α’s N-terminal tail, which strengt...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimojo, Hideaki, Kawaguchi, Ayumi, Oda, Takashi, Hashiguchi, Nobuto, Omori, Satoshi, Moritsugu, Kei, Kidera, Akinori, Hiragami-Hamada, Kyoko, Nakayama, Jun-ichi, Sato, Mamoru, Nishimura, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776139/
https://www.ncbi.nlm.nih.gov/pubmed/26934956
http://dx.doi.org/10.1038/srep22527

Ejemplares similares

Ejemplares similares