Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

The activation of P2X7 receptor (P2X7R) on M1 polarized macrophages induces the assembly of the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines and the establishment of the inflammatory response. However, P2X7R signaling to the NLRP3 inflammasome is uncoupled on M2 macrophage...

Descripción completa

Detalles Bibliográficos
Autores principales: de Torre-Minguela, Carlos, Barberà-Cremades, Maria, Gómez, Ana I., Martín-Sánchez, Fátima, Pelegrín, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776275/
https://www.ncbi.nlm.nih.gov/pubmed/26935289
http://dx.doi.org/10.1038/srep22586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776275/
https://www.ncbi.nlm.nih.gov/pubmed/26935289
http://dx.doi.org/10.1038/srep22586

Ejemplares similares