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Structural Insight into Substrate Selectivity of Erwinia chrysanthemil-Asparaginase
[Image: see text] l-Asparaginases of bacterial origin are a mainstay of acute lymphoblastic leukemia treatment. The mechanism of action of these enzyme drugs is associated with their capacity to deplete the amino acid l-asparagine from the blood. However, clinical use of bacterial l-asparaginases is...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776285/ https://www.ncbi.nlm.nih.gov/pubmed/26855287 http://dx.doi.org/10.1021/acs.biochem.5b01351 |