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HOT mutation screening in human glioblastomas

AIMS: Somatic mutations in IDH1 and IDH2 are described in glioblastomas (GBMs). Mutant IDH1 and IDH2 reduce α-KG to D-2HG which accumulates, and is proposed to promote tumorigenesis. HOT catalyzes the conversion of γ-hydroxybutyrate to succinic semialdehyde in a reaction that produces D-2HG. Since i...

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Detalles Bibliográficos
Autores principales:	Krell, Daniel, Mulholland, Paul, Stebbing, Justin, Tomlinson, Ian, Bardella, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Science Ltd 2015
Materias:	Preliminary Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776344/ https://www.ncbi.nlm.nih.gov/pubmed/26948489 http://dx.doi.org/10.4155/fso.15.20

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