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Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges

OBJECTIVE: Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight‐based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after in...

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Autores principales: Ferrand, Rashida A., Briggs, Datonye, Ferguson, Jane, Penazzato, Martina, Armstrong, Alice, MacPherson, Peter, Ross, David A., Kranzer, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776345/
https://www.ncbi.nlm.nih.gov/pubmed/26681359
http://dx.doi.org/10.1111/tmi.12656
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author Ferrand, Rashida A.
Briggs, Datonye
Ferguson, Jane
Penazzato, Martina
Armstrong, Alice
MacPherson, Peter
Ross, David A.
Kranzer, Katharina
author_facet Ferrand, Rashida A.
Briggs, Datonye
Ferguson, Jane
Penazzato, Martina
Armstrong, Alice
MacPherson, Peter
Ross, David A.
Kranzer, Katharina
author_sort Ferrand, Rashida A.
collection PubMed
description OBJECTIVE: Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight‐based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART. METHODS: MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included. RESULTS: From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%. CONCLUSION: Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.
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spelling pubmed-47763452016-03-03 Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges Ferrand, Rashida A. Briggs, Datonye Ferguson, Jane Penazzato, Martina Armstrong, Alice MacPherson, Peter Ross, David A. Kranzer, Katharina Trop Med Int Health Reviews OBJECTIVE: Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight‐based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART. METHODS: MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included. RESULTS: From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%. CONCLUSION: Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents. John Wiley and Sons Inc. 2016-01-10 2016-03 /pmc/articles/PMC4776345/ /pubmed/26681359 http://dx.doi.org/10.1111/tmi.12656 Text en © 2015 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ferrand, Rashida A.
Briggs, Datonye
Ferguson, Jane
Penazzato, Martina
Armstrong, Alice
MacPherson, Peter
Ross, David A.
Kranzer, Katharina
Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title_full Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title_fullStr Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title_full_unstemmed Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title_short Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
title_sort viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776345/
https://www.ncbi.nlm.nih.gov/pubmed/26681359
http://dx.doi.org/10.1111/tmi.12656
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