C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

INTRODUCTION: Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options. The pathogenesis of the acute motor axonal neuropathy (AMAN) variant is mediated by comple...

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Detalles Bibliográficos
Autores principales: McGonigal, Rhona, Cunningham, Madeleine E., Yao, Denggao, Barrie, Jennifer A., Sankaranarayanan, Sethu, Fewou, Simon N., Furukawa, Koichi, Yednock, Ted A., Willison, Hugh J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776408/
https://www.ncbi.nlm.nih.gov/pubmed/26936605
http://dx.doi.org/10.1186/s40478-016-0291-x

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