Enhancing full-length antibody production by signal peptide engineering

BACKGROUND: Protein secretion to the periplasm of Escherichia coli offers an attractive route for producing heterologous proteins including antibodies. In this approach, a signal peptide is fused to the N-terminus of the heterologous protein. The signal peptide mediates translocation of the heterolo...

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Detalles Bibliográficos
Autores principales: Zhou, Yizhou, Liu, Peter, Gan, Yutian, Sandoval, Wendy, Katakam, Anand Kumar, Reichelt, Mike, Rangell, Linda, Reilly, Dorothea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776426/
https://www.ncbi.nlm.nih.gov/pubmed/26935575
http://dx.doi.org/10.1186/s12934-016-0445-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776426/
https://www.ncbi.nlm.nih.gov/pubmed/26935575
http://dx.doi.org/10.1186/s12934-016-0445-3

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