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Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development
Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776690/ https://www.ncbi.nlm.nih.gov/pubmed/26955067 http://dx.doi.org/10.1093/biosci/biu179 |
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author | Veland, Iben Rønn Lindbæk, Louise Christensen, Søren Tvorup |
author_facet | Veland, Iben Rønn Lindbæk, Louise Christensen, Søren Tvorup |
author_sort | Veland, Iben Rønn |
collection | PubMed |
description | Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathies. Mounting evidence has demonstrated that primary cilia coordinate multiple activities that are required for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration. |
format | Online Article Text |
id | pubmed-4776690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47766902016-03-07 Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development Veland, Iben Rønn Lindbæk, Louise Christensen, Søren Tvorup Bioscience Overview Articles Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathies. Mounting evidence has demonstrated that primary cilia coordinate multiple activities that are required for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration. Oxford University Press 2014-11-25 2014-12-01 /pmc/articles/PMC4776690/ /pubmed/26955067 http://dx.doi.org/10.1093/biosci/biu179 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of the American Institute of Biological Sciences. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Overview Articles Veland, Iben Rønn Lindbæk, Louise Christensen, Søren Tvorup Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title | Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title_full | Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title_fullStr | Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title_full_unstemmed | Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title_short | Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development |
title_sort | linking the primary cilium to cell migration in tissue repair and brain development |
topic | Overview Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776690/ https://www.ncbi.nlm.nih.gov/pubmed/26955067 http://dx.doi.org/10.1093/biosci/biu179 |
work_keys_str_mv | AT velandibenrønn linkingtheprimaryciliumtocellmigrationintissuerepairandbraindevelopment AT lindbæklouise linkingtheprimaryciliumtocellmigrationintissuerepairandbraindevelopment AT christensensørentvorup linkingtheprimaryciliumtocellmigrationintissuerepairandbraindevelopment |