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Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐IL‐15 antibody Hu714MuXHu in cynomolgus monkeys

Hu714MuXHu is a recombinant chimeric murine‐human monoclonal antibody directed against interleukin‐15 (IL‐15), a proinflammatory cytokine associated with memory CD8+ and natural killer (NK) T‐cell activation and implicated in the pathogenesis of inflammatory diseases. A pharmacokinetic‐pharmacodynam...

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Detalles Bibliográficos
Autores principales:	Pan, Wei. J., Li, Hong, Xiao, Jim J., Horner, Michelle J., Lebrec, Herve N., Butz, Eric A., Kaliyaperumal, Arunan, Cheah, Tsui C., Ortiz, Robert C., Prokop, Samantha P., Buntich, Sabina A., Boren, Babette M., Wolford, Suzanne T., Tsuji, Wayne H., Wienkers, Larry C., Köck, Kathleen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777250/ https://www.ncbi.nlm.nih.gov/pubmed/27022472 http://dx.doi.org/10.1002/prp2.199

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