Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices

Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and th...

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Detalles Bibliográficos
Autores principales: Le Saux, Guillaume, Plawinski, Laurent, Nlate, Sylvain, Ripoche, Jean, Buffeteau, Thierry, Durrieu, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777356/
https://www.ncbi.nlm.nih.gov/pubmed/26939131
http://dx.doi.org/10.1371/journal.pone.0150706
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author Le Saux, Guillaume
Plawinski, Laurent
Nlate, Sylvain
Ripoche, Jean
Buffeteau, Thierry
Durrieu, Marie-Christine
author_facet Le Saux, Guillaume
Plawinski, Laurent
Nlate, Sylvain
Ripoche, Jean
Buffeteau, Thierry
Durrieu, Marie-Christine
author_sort Le Saux, Guillaume
collection PubMed
description Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.
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spelling pubmed-47773562016-03-10 Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices Le Saux, Guillaume Plawinski, Laurent Nlate, Sylvain Ripoche, Jean Buffeteau, Thierry Durrieu, Marie-Christine PLoS One Research Article Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells. Public Library of Science 2016-03-03 /pmc/articles/PMC4777356/ /pubmed/26939131 http://dx.doi.org/10.1371/journal.pone.0150706 Text en © 2016 Le Saux et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Le Saux, Guillaume
Plawinski, Laurent
Nlate, Sylvain
Ripoche, Jean
Buffeteau, Thierry
Durrieu, Marie-Christine
Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title_full Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title_fullStr Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title_full_unstemmed Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title_short Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
title_sort beneficial effect of covalently grafted α-msh on endothelial release of inflammatory mediators for applications in implantable devices
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777356/
https://www.ncbi.nlm.nih.gov/pubmed/26939131
http://dx.doi.org/10.1371/journal.pone.0150706
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