Cargando…
An Evidenced-Based Scale of Disease Severity following Human Challenge with Enteroxigenic Escherichia coli
BACKGROUND: Experimental human challenge models have played a major role in enhancing our understanding of infectious diseases. Primary outcomes have typically utilized overly simplistic outcomes that fail to entirely account for complex illness syndromes. We sought to characterize clinical outcomes...
Autores principales: | Porter, Chad K., Riddle, Mark S., Alcala, Ashley N., Sack, David A., Harro, Clayton, Chakraborty, Subhra, Gutierrez, Ramiro L., Savarino, Stephen J., Darsley, Michael, McKenzie, Robin, DeNearing, Barbara, Steinsland, Hans, Tribble, David R., Bourgeois, A. Louis |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777366/ https://www.ncbi.nlm.nih.gov/pubmed/26938983 http://dx.doi.org/10.1371/journal.pone.0149358 |
Ejemplares similares
-
Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge
por: Harro, Clayton, et al.
Publicado: (2019) -
Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers
por: Chakraborty, Subhra, et al.
Publicado: (2018) -
Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection
por: Chakraborty, Subhra, et al.
Publicado: (2019) -
Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score
por: Porter, Chad K., et al.
Publicado: (2018) -
Development of a novel multiplex electrochemiluminescent-based immunoassay to aid enterotoxigenic Escherichia coli vaccine development and evaluations
por: Chakraborty, Subhra, et al.
Publicado: (2019)