Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro

Platinum-based combination chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). While cisplatin is effective, its use is not curative and resistance often emerges. As a consequence of microenvironmental heterogeneity, many tumour cells are exposed to sub-lethal dos...

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Detalles Bibliográficos
Autores principales: Leung, Ada W. Y., Hung, Stacy S., Backstrom, Ian, Ricaurte, Daniel, Kwok, Brian, Poon, Steven, McKinney, Steven, Segovia, Romulo, Rawji, Jenna, Qadir, Mohammed A., Aparicio, Samuel, Stirling, Peter C., Steidl, Christian, Bally, Marcel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777418/
https://www.ncbi.nlm.nih.gov/pubmed/26938915
http://dx.doi.org/10.1371/journal.pone.0150675

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