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PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests that another viral RNA sensor, protein kinase R (PKR)...

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Detalles Bibliográficos
Autores principales:	Pham, Alissa M., Santa Maria, Felicia Gilfoy, Lahiri, Tanaya, Friedman, Eugene, Marié, Isabelle J., Levy, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777437/ https://www.ncbi.nlm.nih.gov/pubmed/26939124 http://dx.doi.org/10.1371/journal.ppat.1005489

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