MicroRNAs as regulators of apoptosis mechanisms in cancer

MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and res...

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Autores principales: PILECZKI, VALENTINA, COJOCNEANU-PETRIC, ROXANA, MARALANI, MAHAFARIN, NEAGOE, IOANA BERINDAN, SANDULESCU, ROBERT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iuliu Hatieganu University of Medicine and Pharmacy 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777469/
https://www.ncbi.nlm.nih.gov/pubmed/27004025
http://dx.doi.org/10.15386/cjmed-512
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author PILECZKI, VALENTINA
COJOCNEANU-PETRIC, ROXANA
MARALANI, MAHAFARIN
NEAGOE, IOANA BERINDAN
SANDULESCU, ROBERT
author_facet PILECZKI, VALENTINA
COJOCNEANU-PETRIC, ROXANA
MARALANI, MAHAFARIN
NEAGOE, IOANA BERINDAN
SANDULESCU, ROBERT
author_sort PILECZKI, VALENTINA
collection PubMed
description MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and resistance to treatment. The first part of this review discusses miRNAs function in the intrinsic and extrinsic pathways of apoptosis. Due to the fact that many miRNAs that regulate apoptosis have been shown to play a major role in tumor cell resistance to treatment, in the second part of the review we aim at discussing miRNAs potential in becoming curative molecules.
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spelling pubmed-47774692016-03-21 MicroRNAs as regulators of apoptosis mechanisms in cancer PILECZKI, VALENTINA COJOCNEANU-PETRIC, ROXANA MARALANI, MAHAFARIN NEAGOE, IOANA BERINDAN SANDULESCU, ROBERT Clujul Med Reviews MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and resistance to treatment. The first part of this review discusses miRNAs function in the intrinsic and extrinsic pathways of apoptosis. Due to the fact that many miRNAs that regulate apoptosis have been shown to play a major role in tumor cell resistance to treatment, in the second part of the review we aim at discussing miRNAs potential in becoming curative molecules. Iuliu Hatieganu University of Medicine and Pharmacy 2016 2016-01-15 /pmc/articles/PMC4777469/ /pubmed/27004025 http://dx.doi.org/10.15386/cjmed-512 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Reviews
PILECZKI, VALENTINA
COJOCNEANU-PETRIC, ROXANA
MARALANI, MAHAFARIN
NEAGOE, IOANA BERINDAN
SANDULESCU, ROBERT
MicroRNAs as regulators of apoptosis mechanisms in cancer
title MicroRNAs as regulators of apoptosis mechanisms in cancer
title_full MicroRNAs as regulators of apoptosis mechanisms in cancer
title_fullStr MicroRNAs as regulators of apoptosis mechanisms in cancer
title_full_unstemmed MicroRNAs as regulators of apoptosis mechanisms in cancer
title_short MicroRNAs as regulators of apoptosis mechanisms in cancer
title_sort micrornas as regulators of apoptosis mechanisms in cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777469/
https://www.ncbi.nlm.nih.gov/pubmed/27004025
http://dx.doi.org/10.15386/cjmed-512
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