Cargando…

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells

Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes. However, its role in liver injury and fibrogenesis has not been elucidated so far. In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siegmund, Sören V., Schlosser, Monika, Schildberg, Frank A., Seki, Ekihiro, De Minicis, Samuele, Uchinami, Hiroshi, Kuntzen, Christian, Knolle, Percy A., Strassburg, Christian P., Schwabe, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777566/ https://www.ncbi.nlm.nih.gov/pubmed/26937641 http://dx.doi.org/10.1371/journal.pone.0150893

Ejemplares similares

Origin of myofibroblasts in liver fibrosis
por: Brenner, David A, et al.
Publicado: (2012)

Tumor Suppressor Down-Regulation Promotes Hepatocyte Proliferation: A New GANKster on the Block
por: Pimienta, Michael, et al.
Publicado: (2018)

Involvement of Galectin-1 and Galectin-3 in Proliferation and Migration of Rat Hepatic Stellate Cells in Culture
por: Maeda, Naoto, et al.
Publicado: (2004)

Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling
por: Tao, Le, et al.
Publicado: (2019)

GIV/Girdin is a central hub for pro-fibrogenic signalling networks during liver fibrosis
por: Lopez-Sanchez, Inmaculada, et al.
Publicado: (2014)

Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury
por: Czech, Torrey Y., et al.
Publicado: (2019)

Circumferential esophageal leiomyoma
por: Antonini, Filippo, et al.
Publicado: (2015)

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism
por: Li, Jiang, et al.
Publicado: (2017)

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
por: Seki, Ekihiro
Publicado: (2014)

Acrolein, a New Villain in the Development of Alcoholic Liver Disease
por: Seki, Ekihiro
Publicado: (2016)

Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice
por: Chung, Kyoung-Jin, et al.
Publicado: (2023)

Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells
por: Estaras, Matias, et al.
Publicado: (2022)

Expression of the Peroxisome Proliferator-Activated Receptors (PPARs) in the Hepatic Stellate Cells
por: Sato, Takeya, et al.
Publicado: (2004)

Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis
por: Tsuchiya, Yuichi, et al.
Publicado: (2023)

A new mechanism of action of glucagon‐like peptide‐1 agonist in hepatic steatosis: Promotion of hepatic insulin clearance through induction of carcinoembryonic antigen‐related cell adhesion molecule 1
por: Czech, Torrey Y., et al.
Publicado: (2018)

Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms
por: Yang, Ling, et al.
Publicado: (2012)

Nuclear Receptors: Opening Up New Avenues of Pediatric Fatty Liver Research
por: Pandyarajan, Vijay, et al.
Publicado: (2018)

Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD
por: Kim, Jieun, et al.
Publicado: (2021)

Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets
por: Kim, Jieun, et al.
Publicado: (2023)

FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis
por: Kim, Jieun, et al.
Publicado: (2023)

A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
por: Wang, Xiaohang, et al.
Publicado: (2018)

Neurotropin Suppresses Inflammatory Cytokine Expression and Cell Death through Suppression of NF-κB and JNK in Hepatocytes
por: Zhang, Bi, et al.
Publicado: (2014)

In vivo and in vitro Interactions between Human Colon Carcinoma Cells and Hepatic Stellate Cells
por: Shimizu, Sadatoshi, et al.
Publicado: (2000)

Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro
por: Zhang, Li-Ting, et al.
Publicado: (2018)

Platelet Interactions with Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells Lead to Hepatocyte Proliferation
por: Meyer, Jeremy, et al.
Publicado: (2020)

Tu1256: METFORMIN USE IS ASSOCIATED WITH LESS FREQUENT SEVERE LIVER INJURY UPON HOSPITAL ADMISSIN WITH COVID-19
por: Kuntzen, Christian, et al.
Publicado: (2022)

In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations
por: Lee, Young-Sun, et al.
Publicado: (2023)

Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells
por: Li, Jun, et al.
Publicado: (2015)

Aquaporin 11-Dependent Inhibition of Proliferation by Deuterium Oxide in Activated Hepatic Stellate Cells
por: Lee, Phil Jun, et al.
Publicado: (2018)

Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology
por: Mederacke, Ingmar, et al.
Publicado: (2013)

Stellate cells are mesenchymal stem cells
por: Kordes, Claus, et al.
Publicado: (2014)

Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection
por: Abdullah, Zeinab, et al.
Publicado: (2012)

Shedding light on stellate cells
por: Alexander, Andrew S, et al.
Publicado: (2018)

Stellate cells in health and disease
por: Vaiphei, Kim
Publicado: (2017)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Immunological functions of liver sinusoidal endothelial cells
por: Knolle, Percy A, et al.
Publicado: (2016)

Intercellular Adhesive Structures Between Stellate Cells – An Analysis in Cultured Human Hepatic Stellate Cells
por: Imai, Katsuyuki, et al.
Publicado: (2004)

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
por: Zhong, Xiaolin, et al.
Publicado: (2020)

Intestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine
por: Pimienta, Michael, et al.
Publicado: (2019)

Alcoholic liver disease: A current molecular and clinical perspective()
por: Ohashi, Koichiro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dl9tven47arlq7d7fjptce7idv