Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization

Monoacylglycerol O-acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DG), a triacylglycerol precursor and potential peripheral target for novel anti-obesity therapeutics. High-throughput screening identified lead compounds with MGAT2 inhibitory activity. Through structural modific...

Descripción completa

Detalles Bibliográficos
Autores principales: Take, Kazumi, Mochida, Taisuke, Maki, Toshiyuki, Satomi, Yoshinori, Hirayama, Megumi, Nakakariya, Masanori, Amano, Nobuyuki, Adachi, Ryutaro, Sato, Kenjiro, Kitazaki, Tomoyuki, Takekawa, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777574/
https://www.ncbi.nlm.nih.gov/pubmed/26938273
http://dx.doi.org/10.1371/journal.pone.0150976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777574/
https://www.ncbi.nlm.nih.gov/pubmed/26938273
http://dx.doi.org/10.1371/journal.pone.0150976

Ejemplares similares