Cargando…

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization

Monoacylglycerol O-acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DG), a triacylglycerol precursor and potential peripheral target for novel anti-obesity therapeutics. High-throughput screening identified lead compounds with MGAT2 inhibitory activity. Through structural modific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Take, Kazumi, Mochida, Taisuke, Maki, Toshiyuki, Satomi, Yoshinori, Hirayama, Megumi, Nakakariya, Masanori, Amano, Nobuyuki, Adachi, Ryutaro, Sato, Kenjiro, Kitazaki, Tomoyuki, Takekawa, Shiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777574/ https://www.ncbi.nlm.nih.gov/pubmed/26938273 http://dx.doi.org/10.1371/journal.pone.0150976

Ejemplares similares

Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet
por: Mochida, Taisuke, et al.
Publicado: (2020)

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans
por: Liss, Kim H. H., et al.
Publicado: (2018)

Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway
por: Petrie, James R., et al.
Publicado: (2012)

The monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells
por: McFie, Pamela J., et al.
Publicado: (2022)

Correction: Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway
por: Petrie, James R., et al.
Publicado: (2012)

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice
por: Hall, Angela M., et al.
Publicado: (2014)

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
por: Yu, Jung Hwan, et al.
Publicado: (2016)

Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis
por: Lee, Yoo Jeong, et al.
Publicado: (2017)

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes
por: Hayashi, Yasuhiro, et al.
Publicado: (2014)

Transcriptional and biochemical responses of monoacylglycerol acyltransferase-mediated oil synthesis and associated senescence-like responses in Nicotiana benthamiana
por: Divi, Uday K., et al.
Publicado: (2014)

Novel Cell-Based Assay to Investigate Monoacylglycerol Acyltransferase 2 Inhibitory Activity Using HIEC-6 Cell Line
por: Singh, Yeshvanthi, et al.
Publicado: (2021)

Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1
por: Lutkewitte, Andrew J., et al.
Publicado: (2021)

Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells
por: Sankella, Shireesha, et al.
Publicado: (2016)

Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression
por: Baek, Kyung-Wan, et al.
Publicado: (2020)

Monoacylglycerol Lipase Regulates Fever Response
por: Sanchez-Alavez, Manuel, et al.
Publicado: (2015)

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
por: Rengachari, Srinivasan, et al.
Publicado: (2013)

Structure of Microemulsion Formulated with Monoacylglycerols in the Presence of Polyols and Ethanol
por: Szumała, Patrycja
Publicado: (2014)

Conformational gating, dynamics and allostery in human monoacylglycerol lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2020)

Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer
por: Li, Xin, et al.
Publicado: (2019)

Novel Polyvinyl Butyral/Monoacylglycerol Nanofibrous Membrane with Antifouling Activity
por: Peer, Petra, et al.
Publicado: (2020)

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease
por: Tardelli, Matteo
Publicado: (2020)

Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis
por: Tang, Zhiyuan, et al.
Publicado: (2020)

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases
por: Zanfirescu, Anca, et al.
Publicado: (2021)

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
por: Allaire, Manon, et al.
Publicado: (2023)

Glycerophosphate/Acylglycerophosphate Acyltransferases
por: Yamashita, Atsushi, et al.
Publicado: (2014)

Postprandial Hyperlipidemia: Its Pathophysiology, Diagnosis, Atherogenesis, and Treatments
por: Yanai, Hidekatsu, et al.
Publicado: (2023)

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
por: Schlosburg, Joel E., et al.
Publicado: (2010)

Excitation-dependent visible fluorescence in decameric nanoparticles with monoacylglycerol cluster chromophores
por: Lee, Kwang-Ming, et al.
Publicado: (2013)

Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
por: Costola-de-Souza, Carolina, et al.
Publicado: (2013)

Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2018)

Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma
por: Zhang, Hao, et al.
Publicado: (2020)

A New Ultrasensitive Bioluminescence-Based Method for Assaying Monoacylglycerol Lipase
por: Miceli, Matteo, et al.
Publicado: (2021)

Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes
por: Chen, Chu
Publicado: (2022)

Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans
por: Muñoz, Camilo F., et al.
Publicado: (2019)

Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum123
por: Chen, Yao, et al.
Publicado: (2016)

Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism
por: Heier, Christoph, et al.
Publicado: (2016)

Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis
por: Wang, Jing, et al.
Publicado: (2022)

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
por: Bononi, Giulia, et al.
Publicado: (2022)

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus
por: Oku, Naoya, et al.
Publicado: (2023)

Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2
por: Tarui, Megumi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fa334ele0653d6o9ud7032b5bk