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Divergent clonal evolution of castration resistant neuroendocrine prostate cancer
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, wherein tumor cells demonstrate low to absent AR expression and often neuroendocrine features. The etiology and molecular basis for these “alternative” treatm...
Autores principales: | Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V.S.K., Varambally, Sooryanarayana, Tomlins, Scott A., Nanus, David M., Tagawa, Scott T., Van Allen, Eliezer M., Elemento, Olivier, Sboner, Andrea, Garraway, Levi A., Rubin, Mark A., Demichelis, Francesca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777652/ https://www.ncbi.nlm.nih.gov/pubmed/26855148 http://dx.doi.org/10.1038/nm.4045 |
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