Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients

Hematopoietic stem-cell transplantation (HSCT) is currently the only curative therapeutic option for the treatment of thalassemia. In spite of the high cure rate, HSCT can lead to life-threatening adverse events in some patients. Busulfan (Bu) is a key component of the conditioning regimen prior to...

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Detalles Bibliográficos
Autores principales: Ansari, M, Huezo-Diaz, P, Rezgui, M A, Marktel, S, Duval, M, Bittencourt, H, Cappelli, B, Krajinovic, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777888/
https://www.ncbi.nlm.nih.gov/pubmed/26691424
http://dx.doi.org/10.1038/bmt.2015.321

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