Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

Heterogeneity is a hallmark of glioblastoma with intratumoral heterogeneity contributing to variability in responses and resistance to standard treatments. Promoter methylation status of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is the most important clinical biomarker in...

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Detalles Bibliográficos
Autores principales: Parker, Nicole R., Hudson, Amanda L., Khong, Peter, Parkinson, Jonathon F., Dwight, Trisha, Ikin, Rowan J., Zhu, Ying, Cheng, Zhangkai Jason, Vafaee, Fatemeh, Chen, Jason, Wheeler, Helen R., Howell, Viive M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778014/
https://www.ncbi.nlm.nih.gov/pubmed/26940435
http://dx.doi.org/10.1038/srep22477

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