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Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis
The prognostic value of the platelet-to-lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) remains controversial. We therefore conducted a meta-analysis of published studies to determine the prognostic value of PLR in NSCLC. A systematic search was performed in PubMed, Web of Science and E...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778054/ https://www.ncbi.nlm.nih.gov/pubmed/26939789 http://dx.doi.org/10.1038/srep22618 |
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author | Zhang, Hua Gao, Liuwei Zhang, Bin Zhang, Lianmin wang, Changli |
author_facet | Zhang, Hua Gao, Liuwei Zhang, Bin Zhang, Lianmin wang, Changli |
author_sort | Zhang, Hua |
collection | PubMed |
description | The prognostic value of the platelet-to-lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) remains controversial. We therefore conducted a meta-analysis of published studies to determine the prognostic value of PLR in NSCLC. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. The data and characteristics of each study were extracted, and the hazard ratio (HR) at a 95% confidence interval (CI) was calculated to estimate the effect. We also performed subgroup and meta-regression analyses. A total of 2,889 patients in 12 studies were enrolled in this meta-analysis, and the pooled HR of 1.492 (95% CI: 1.231–1.807, P < 0.001) indicated that patients with an elevated PLR are expected to have a shorter overall survival (OS) after treatment. This meta-analysis indicates that a high PLR might be a predictive factor of poor prognosis in NSCLC. Further large-cohort studies are needed to confirm these findings. |
format | Online Article Text |
id | pubmed-4778054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47780542016-03-09 Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis Zhang, Hua Gao, Liuwei Zhang, Bin Zhang, Lianmin wang, Changli Sci Rep Article The prognostic value of the platelet-to-lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) remains controversial. We therefore conducted a meta-analysis of published studies to determine the prognostic value of PLR in NSCLC. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. The data and characteristics of each study were extracted, and the hazard ratio (HR) at a 95% confidence interval (CI) was calculated to estimate the effect. We also performed subgroup and meta-regression analyses. A total of 2,889 patients in 12 studies were enrolled in this meta-analysis, and the pooled HR of 1.492 (95% CI: 1.231–1.807, P < 0.001) indicated that patients with an elevated PLR are expected to have a shorter overall survival (OS) after treatment. This meta-analysis indicates that a high PLR might be a predictive factor of poor prognosis in NSCLC. Further large-cohort studies are needed to confirm these findings. Nature Publishing Group 2016-03-04 /pmc/articles/PMC4778054/ /pubmed/26939789 http://dx.doi.org/10.1038/srep22618 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhang, Hua Gao, Liuwei Zhang, Bin Zhang, Lianmin wang, Changli Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title | Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title_full | Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title_fullStr | Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title_full_unstemmed | Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title_short | Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
title_sort | prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778054/ https://www.ncbi.nlm.nih.gov/pubmed/26939789 http://dx.doi.org/10.1038/srep22618 |
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