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SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) degeneration resulting from nutrient diffusion disorders. Although cell senescence resulting from oxidative stress is known to contribute to degeneration, no studies concerning the role of senescence in CEP d...

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Detalles Bibliográficos
Autores principales:	Zhou, Nian, Lin, Xin, Dong, Wen, Huang, Wei, Jiang, Wei, Lin, Liangbo, Qiu, Quanhe, Zhang, Xiaojun, Shen, Jieliang, Song, Zhaojun, Liang, Xi, Hao, Jie, Wang, Dawu, Hu, Zhenming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778056/ https://www.ncbi.nlm.nih.gov/pubmed/26940203 http://dx.doi.org/10.1038/srep22628

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