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Pedal edema associated with atypical antipsychotics

This study describes a patient diagnosed as a case of bipolar affective disorder complaining of bothersome incidence of pedal edema 1 month after the initiation of atypical antipsychotic regimen with risperidone and quetiapine. All hematological and biochemical profiles were found to be normal. On d...

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Autores principales: Munshi, Santanu, Mukherjee, Shatavisa, Saha, Indranil, Sen, Sukanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778216/
https://www.ncbi.nlm.nih.gov/pubmed/26997731
http://dx.doi.org/10.4103/0253-7613.174571
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author Munshi, Santanu
Mukherjee, Shatavisa
Saha, Indranil
Sen, Sukanta
author_facet Munshi, Santanu
Mukherjee, Shatavisa
Saha, Indranil
Sen, Sukanta
author_sort Munshi, Santanu
collection PubMed
description This study describes a patient diagnosed as a case of bipolar affective disorder complaining of bothersome incidence of pedal edema 1 month after the initiation of atypical antipsychotic regimen with risperidone and quetiapine. All hematological and biochemical profiles were found to be normal. On discontinuation of risperidone, the condition remained unresolved even after 2 weeks, and the edema progressed reaching her calves. On tapering the dose of quetiapine, she started showing gradual improvement in edematous condition. Quetiapine was slowly discontinued. No further recurrence of edema occurred, and hence, no further medication changes were implemented. Pedal edema was found to be resolved within weeks of dechallenge of the regimen. Naranjo adverse drug reaction probability scale gave a score of 7 which denotes “probable” adverse drug reaction with quetiapine.
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spelling pubmed-47782162016-03-18 Pedal edema associated with atypical antipsychotics Munshi, Santanu Mukherjee, Shatavisa Saha, Indranil Sen, Sukanta Indian J Pharmacol Drug Watch This study describes a patient diagnosed as a case of bipolar affective disorder complaining of bothersome incidence of pedal edema 1 month after the initiation of atypical antipsychotic regimen with risperidone and quetiapine. All hematological and biochemical profiles were found to be normal. On discontinuation of risperidone, the condition remained unresolved even after 2 weeks, and the edema progressed reaching her calves. On tapering the dose of quetiapine, she started showing gradual improvement in edematous condition. Quetiapine was slowly discontinued. No further recurrence of edema occurred, and hence, no further medication changes were implemented. Pedal edema was found to be resolved within weeks of dechallenge of the regimen. Naranjo adverse drug reaction probability scale gave a score of 7 which denotes “probable” adverse drug reaction with quetiapine. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4778216/ /pubmed/26997731 http://dx.doi.org/10.4103/0253-7613.174571 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Drug Watch
Munshi, Santanu
Mukherjee, Shatavisa
Saha, Indranil
Sen, Sukanta
Pedal edema associated with atypical antipsychotics
title Pedal edema associated with atypical antipsychotics
title_full Pedal edema associated with atypical antipsychotics
title_fullStr Pedal edema associated with atypical antipsychotics
title_full_unstemmed Pedal edema associated with atypical antipsychotics
title_short Pedal edema associated with atypical antipsychotics
title_sort pedal edema associated with atypical antipsychotics
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778216/
https://www.ncbi.nlm.nih.gov/pubmed/26997731
http://dx.doi.org/10.4103/0253-7613.174571
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