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Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI
BACKGROUND: This study aimed to evaluate the diagnostic value of the D value, D* value, and f magnitude for identifying benign and malignant hepatic tumors using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). MATERIAL/METHODS: Data of 89 cases (123 lesions) with hepatic tumor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778409/ https://www.ncbi.nlm.nih.gov/pubmed/26931063 http://dx.doi.org/10.12659/MSM.895909 |
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author | Wang, Mingjie Li, Xudan Zou, Jianxun Chen, Xugao Chen, Shuyan Xiang, Wanqing |
author_facet | Wang, Mingjie Li, Xudan Zou, Jianxun Chen, Xugao Chen, Shuyan Xiang, Wanqing |
author_sort | Wang, Mingjie |
collection | PubMed |
description | BACKGROUND: This study aimed to evaluate the diagnostic value of the D value, D* value, and f magnitude for identifying benign and malignant hepatic tumors using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). MATERIAL/METHODS: Data of 89 cases (123 lesions) with hepatic tumor confirmed by surgical pathology and postoperative follow-up were retrospectively collected. Among these cases, 40 cases were benign hepatic tumors (57 lesions) and 49 cases were malignant hepatic tumors (66 lesions). All subjects underwent conventional MRI with T(1)WI, T(2)WI, multi-b-value DWI, and dynamic enhanced LAVA scan. Diffusion-weighted images with 11 b values (0, 10, 20, 30, 50, 80, 100, 200, 400, 800, and 1000 s/mm(2)) were obtained to calculate true molecular diffusion (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (f). The diagnostic performance in differentiating between malignant and benign hepatic lesions was analyzed. RESULTS: Malignant lesions had a significantly lower D value ([1.04±0.34]×10(−3) mm(2)/s) and D* value ([16.5±7.7]×10(−3) mm(2)/s) compared to benign lesions (D value: [1.70±0.55]×10(−3) mm(2)/s, P<0.01; D* value: [21.7±9.9]×10(−3) mm(2)/s, P<0.01). There was no statistically significant difference in f values between malignant (23.3±9.5) and benign lesions (33.5±14.9, P=0.13). In addition, D exhibited a better diagnostic performance than D* in terms of the area under the curve, sensitivity, and specificity when identifying malignancies from benign lesions. CONCLUSIONS: D and D* are significant parameters for diagnosing hepatic tumors. Moreover, the D value is a more reliable parameter in distinguishing benign and malignant hepatic tumors. |
format | Online Article Text |
id | pubmed-4778409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47784092016-03-16 Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI Wang, Mingjie Li, Xudan Zou, Jianxun Chen, Xugao Chen, Shuyan Xiang, Wanqing Med Sci Monit Clinical Research BACKGROUND: This study aimed to evaluate the diagnostic value of the D value, D* value, and f magnitude for identifying benign and malignant hepatic tumors using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). MATERIAL/METHODS: Data of 89 cases (123 lesions) with hepatic tumor confirmed by surgical pathology and postoperative follow-up were retrospectively collected. Among these cases, 40 cases were benign hepatic tumors (57 lesions) and 49 cases were malignant hepatic tumors (66 lesions). All subjects underwent conventional MRI with T(1)WI, T(2)WI, multi-b-value DWI, and dynamic enhanced LAVA scan. Diffusion-weighted images with 11 b values (0, 10, 20, 30, 50, 80, 100, 200, 400, 800, and 1000 s/mm(2)) were obtained to calculate true molecular diffusion (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (f). The diagnostic performance in differentiating between malignant and benign hepatic lesions was analyzed. RESULTS: Malignant lesions had a significantly lower D value ([1.04±0.34]×10(−3) mm(2)/s) and D* value ([16.5±7.7]×10(−3) mm(2)/s) compared to benign lesions (D value: [1.70±0.55]×10(−3) mm(2)/s, P<0.01; D* value: [21.7±9.9]×10(−3) mm(2)/s, P<0.01). There was no statistically significant difference in f values between malignant (23.3±9.5) and benign lesions (33.5±14.9, P=0.13). In addition, D exhibited a better diagnostic performance than D* in terms of the area under the curve, sensitivity, and specificity when identifying malignancies from benign lesions. CONCLUSIONS: D and D* are significant parameters for diagnosing hepatic tumors. Moreover, the D value is a more reliable parameter in distinguishing benign and malignant hepatic tumors. International Scientific Literature, Inc. 2016-03-02 /pmc/articles/PMC4778409/ /pubmed/26931063 http://dx.doi.org/10.12659/MSM.895909 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Wang, Mingjie Li, Xudan Zou, Jianxun Chen, Xugao Chen, Shuyan Xiang, Wanqing Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title | Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title_full | Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title_fullStr | Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title_full_unstemmed | Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title_short | Evaluation of Hepatic Tumors Using Intravoxel Incoherent Motion Diffusion-Weighted MRI |
title_sort | evaluation of hepatic tumors using intravoxel incoherent motion diffusion-weighted mri |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778409/ https://www.ncbi.nlm.nih.gov/pubmed/26931063 http://dx.doi.org/10.12659/MSM.895909 |
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