The Human Toxome Project

The Human Toxome Project, funded as an NIH Transformative Research grant 2011–2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human brea...

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Autores principales: Bouhifd, Mounir, Andersen, Melvin E., Baghdikian, Christina, Boekelheide, Kim, Crofton, Kevin M., Fornace, Albert J., Kleensang, Andre, Li, Henghong, Livi, Carolina, Maertens, Alexandra, McMullen, Patrick D., Rosenberg, Michael, Thomas, Russell, Vantangoli, Marguerite, Yager, James D., Zhao, Liang, Hartung, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778566/
https://www.ncbi.nlm.nih.gov/pubmed/25742299
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author Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace, Albert J.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
McMullen, Patrick D.
Rosenberg, Michael
Thomas, Russell
Vantangoli, Marguerite
Yager, James D.
Zhao, Liang
Hartung, Thomas
author_facet Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace, Albert J.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
McMullen, Patrick D.
Rosenberg, Michael
Thomas, Russell
Vantangoli, Marguerite
Yager, James D.
Zhao, Liang
Hartung, Thomas
author_sort Bouhifd, Mounir
collection PubMed
description The Human Toxome Project, funded as an NIH Transformative Research grant 2011–2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.
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spelling pubmed-47785662016-03-04 The Human Toxome Project Bouhifd, Mounir Andersen, Melvin E. Baghdikian, Christina Boekelheide, Kim Crofton, Kevin M. Fornace, Albert J. Kleensang, Andre Li, Henghong Livi, Carolina Maertens, Alexandra McMullen, Patrick D. Rosenberg, Michael Thomas, Russell Vantangoli, Marguerite Yager, James D. Zhao, Liang Hartung, Thomas ALTEX Article The Human Toxome Project, funded as an NIH Transformative Research grant 2011–2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies. 2015-03-04 2015 /pmc/articles/PMC4778566/ /pubmed/25742299 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited.
spellingShingle Article
Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace, Albert J.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
McMullen, Patrick D.
Rosenberg, Michael
Thomas, Russell
Vantangoli, Marguerite
Yager, James D.
Zhao, Liang
Hartung, Thomas
The Human Toxome Project
title The Human Toxome Project
title_full The Human Toxome Project
title_fullStr The Human Toxome Project
title_full_unstemmed The Human Toxome Project
title_short The Human Toxome Project
title_sort human toxome project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778566/
https://www.ncbi.nlm.nih.gov/pubmed/25742299
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