Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal

We evaluated a three-dimensional (3D) human oral cell culture that consisted of two types of cells, oral keratinocytes and fibroblasts as a model of oral mucositis which is a debilitating adverse effect of chemotherapy and radiation treatment. The 3D cell culture model was irradiated with 12 or 2 Gy...

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Autores principales: Lambros, Maria P., DeSalvo, Michael K., Mulamalla, Hari Chandana, Moreno, Jonathan, Kondapalli, Lavanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778614/
https://www.ncbi.nlm.nih.gov/pubmed/26981390
http://dx.doi.org/10.1016/j.gdata.2015.12.013
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author Lambros, Maria P.
DeSalvo, Michael K.
Mulamalla, Hari Chandana
Moreno, Jonathan
Kondapalli, Lavanya
author_facet Lambros, Maria P.
DeSalvo, Michael K.
Mulamalla, Hari Chandana
Moreno, Jonathan
Kondapalli, Lavanya
author_sort Lambros, Maria P.
collection PubMed
description We evaluated a three-dimensional (3D) human oral cell culture that consisted of two types of cells, oral keratinocytes and fibroblasts as a model of oral mucositis which is a debilitating adverse effect of chemotherapy and radiation treatment. The 3D cell culture model was irradiated with 12 or 2 Gy, and total RNA was collected 6 h after irradiation to compare global gene expression profiles via microarray analysis. Here we provide detailed methods and analysis on these microarray data, which have been deposited in Gene Expression Omnibus (GEO): GSE62395.
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spelling pubmed-47786142016-03-15 Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal Lambros, Maria P. DeSalvo, Michael K. Mulamalla, Hari Chandana Moreno, Jonathan Kondapalli, Lavanya Genom Data Data in Brief We evaluated a three-dimensional (3D) human oral cell culture that consisted of two types of cells, oral keratinocytes and fibroblasts as a model of oral mucositis which is a debilitating adverse effect of chemotherapy and radiation treatment. The 3D cell culture model was irradiated with 12 or 2 Gy, and total RNA was collected 6 h after irradiation to compare global gene expression profiles via microarray analysis. Here we provide detailed methods and analysis on these microarray data, which have been deposited in Gene Expression Omnibus (GEO): GSE62395. Elsevier 2015-12-19 /pmc/articles/PMC4778614/ /pubmed/26981390 http://dx.doi.org/10.1016/j.gdata.2015.12.013 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data in Brief
Lambros, Maria P.
DeSalvo, Michael K.
Mulamalla, Hari Chandana
Moreno, Jonathan
Kondapalli, Lavanya
Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title_full Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title_fullStr Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title_full_unstemmed Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title_short Genome wide expression after different doses of irradiation of a three-dimensional (3D) model of oral mucosal
title_sort genome wide expression after different doses of irradiation of a three-dimensional (3d) model of oral mucosal
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778614/
https://www.ncbi.nlm.nih.gov/pubmed/26981390
http://dx.doi.org/10.1016/j.gdata.2015.12.013
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