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Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages

Immunological memory has been believed to be a feature of the adaptive immune system for long period, but recent reports suggest that the innate immune system also exhibits memory-like reaction. Although evidence of innate immune memory is accumulating, no in vivo experimental data has clearly impli...

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Detalles Bibliográficos
Autores principales: Yoshida, Keisuke, Renard-Guillet, Claire, Inoue, Kentaro, Shirahige, Katsuhiko, Okada-Hatakeyama, Mariko, Ishii, Shunsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778626/
https://www.ncbi.nlm.nih.gov/pubmed/26981372
http://dx.doi.org/10.1016/j.gdata.2015.11.028
Descripción
Sumario:Immunological memory has been believed to be a feature of the adaptive immune system for long period, but recent reports suggest that the innate immune system also exhibits memory-like reaction. Although evidence of innate immune memory is accumulating, no in vivo experimental data has clearly implicated a molecular mechanism, or even a cell-type, for this phenomenon. In this study of data deposited into Gene Expression Omnibus (GEO) under GSE71111, we analyzed the expression profile of peritoneal macrophages isolated from mice pre-administrated with toll-like receptor (TLR) ligands, mimicking pathogen infection. In these macrophages, increased expression of a group of innate immunity-related genes was sustained over a long period of time, and these genes overlapped with ATF7-regulated genes. We conclude that ATF7 plays an important role in innate immune memory in macrophages.