Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence in response to various signals for bacteria within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat and deacetylated by deacetylase CobB enzymatically in vitro and in vivo in Salmo...

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Detalles Bibliográficos
Autores principales: Ren, Jie, Sang, Yu, Tan, Yongcong, Tao, Jing, Ni, Jinjing, Liu, Shuting, Fan, Xia, Zhao, Wei, Lu, Jie, Wu, Wenjuan, Yao, Yu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778762/
https://www.ncbi.nlm.nih.gov/pubmed/26943369
http://dx.doi.org/10.1371/journal.ppat.1005458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778762/
https://www.ncbi.nlm.nih.gov/pubmed/26943369
http://dx.doi.org/10.1371/journal.ppat.1005458

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