Cargando…

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

CD8 T cells are involved in pathogen clearance and infection-induced pathology in respiratory syncytial virus (RSV) infection. Studying bulk responses masks the contribution of individual CD8 T cell subsets to protective immunity and immunopathology. In particular, the roles of subdominant responses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jie, Haddad, Elias K., Marceau, Joshua, Morabito, Kaitlyn M., Rao, Srinivas S., Filali-Mouhim, Ali, Sekaly, Rafick-Pierre, Graham, Barney S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778879/ https://www.ncbi.nlm.nih.gov/pubmed/26943673 http://dx.doi.org/10.1371/journal.ppat.1005486

Ejemplares similares

Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus K(d)M2(82-90) Epitope Is Transfer Dose-Dependent
por: Morabito, Kaitlyn M., et al.
Publicado: (2016)

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem
por: Tan, Hyon-Xhi, et al.
Publicado: (2019)

Subdominant Antigens in Bacterial Vaccines: AM779 Is Subdominant in the Anaplasma marginale Outer Membrane Vaccine but Does Not Associate with Protective Immunity
por: Albarrak, Saleh M., et al.
Publicado: (2012)

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
por: Sesterhenn, Fabian, et al.
Publicado: (2019)

Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children
por: de Armas, Lesley R., et al.
Publicado: (2021)

Maternal BCG scar is associated with increased infant proinflammatory immune responses
por: Mawa, Patrice Akusa, et al.
Publicado: (2017)

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
por: Caskey, Marina, et al.
Publicado: (2011)

Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
por: Gómez, Carmen Elena, et al.
Publicado: (2012)

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
por: Gómez, Carmen Elena, et al.
Publicado: (2012)

Correction: Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C
por: Gómez, Carmen Elena, et al.
Publicado: (2012)

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
por: Peretz, Yoav, et al.
Publicado: (2012)

A window of opportunity: Subdominant predators can use suboptimal prey
por: Jackson, Kelly A., et al.
Publicado: (2017)

Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus
por: Smit, Joost J., et al.
Publicado: (2006)

Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus–Induced Immunopathology
por: Walzl, Gerhard, et al.
Publicado: (2000)

The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?
por: Sekaly, Rafick-Pierre
Publicado: (2008)

Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis
por: Sabir, Naveed, et al.
Publicado: (2019)

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection
por: Schmidt, Megan E., et al.
Publicado: (2018)

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH
por: Parsons, Andrea J., et al.
Publicado: (2022)

IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice
por: Loebbermann, Jens, et al.
Publicado: (2012)

Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant
por: Butler, Noah S., et al.
Publicado: (2008)

Impurity bound states in fully gapped d-wave superconductors with subdominant order parameters
por: Mashkoori, Mahdi, et al.
Publicado: (2017)

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
por: Graham, Barney S., et al.
Publicado: (2013)

Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study
por: Fletcher, Helen A., et al.
Publicado: (2016)

Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life
por: Buchwald, Andrea G, et al.
Publicado: (2020)

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System – Tuberculosis
por: Poh, Xuan Ying, et al.
Publicado: (2022)

Subdominant Gag-specific anti-HIV efficacy in an HLA-B(∗)57-positive elite controller
por: Leitman, Ellen M., et al.
Publicado: (2016)

Immediate effects of different treatments for the wrist joints of subdominant hands, using electromechanical reaction time
por: Hu, Chunying, et al.
Publicado: (2016)

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes
por: Silva, Murillo, et al.
Publicado: (2017)

Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine
por: Schwerdtfeger, Melanie, et al.
Publicado: (2019)

Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells
por: Freitag, Kirsten, et al.
Publicado: (2021)

Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection
por: Schmidt, Megan E., et al.
Publicado: (2019)

COPD immunopathology
por: Caramori, Gaetano, et al.
Publicado: (2016)

Protective Efficacy of Serially Up-Ranked Subdominant CD8(+) T Cell Epitopes against Virus Challenges
por: Im, Eung-Jun, et al.
Publicado: (2011)

Subdominant Outer Membrane Antigens in Anaplasma marginale: Conservation, Antigenicity, and Protective Capacity Using Recombinant Protein
por: Ducken, Deirdre R., et al.
Publicado: (2015)

Evaluation of effects of different treatments for the wrist joints of subdominant hands using joint proprioception and writing time
por: Hu, Chunying, et al.
Publicado: (2016)

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
por: Chatterjee, Deepyan, et al.
Publicado: (2021)

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
por: Gaucher, Denis, et al.
Publicado: (2008)

Recapitulating adult human immune traits in laboratory mice by normalizing environment
por: Beura, Lalit K., et al.
Publicado: (2016)

IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection
por: Muallem, Gaia, et al.
Publicado: (2017)

Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection
por: Cheon, In Su, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_u7jm922iilk5hml6a0a8e1t8aj