Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Aberrant activation of the hedgehog (Hh) signaling pathway has been implicated in the epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSC) maintenance; both processes can result in tumor progression and treatment resistance in several types of human cancer. Hh cooperates with t...

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Detalles Bibliográficos
Autores principales: Bai, Xiao-Yan, Zhang, Xu-Chao, Yang, Su-Qing, An, She-Juan, Chen, Zhi-Hong, Su, Jian, Xie, Zhi, Gou, Lan-Ying, Wu, Yi-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778934/
https://www.ncbi.nlm.nih.gov/pubmed/26943330
http://dx.doi.org/10.1371/journal.pone.0149370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778934/
https://www.ncbi.nlm.nih.gov/pubmed/26943330
http://dx.doi.org/10.1371/journal.pone.0149370

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