An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers

Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive “Fas apoptosis” to “Fas multisignals” paradigm and the acceptance that Fas-related therapies face a major challenge, as it remains unclear what determines the mode of Fa...

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Detalles Bibliográficos
Autores principales: Chakrabandhu, Krittalak, Huault, Sébastien, Durivault, Jérôme, Lang, Kévin, Ta Ngoc, Ly, Bole, Angelique, Doma, Eszter, Dérijard, Benoit, Gérard, Jean-Pierre, Pierres, Michel, Hueber, Anne-Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778973/
https://www.ncbi.nlm.nih.gov/pubmed/26942442
http://dx.doi.org/10.1371/journal.pbio.1002401

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