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Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy

Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism(1) However, its role in cancer immunopathology and immunotherapy is poorly understood. Using ovarian cancers as our model, we found that enhancer of zeste homolog 2 (EZH2)-mediated histone...

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Detalles Bibliográficos
Autores principales:	Peng, Dongjun, Kryczek, Ilona, Nagarsheth, Nisha, Zhao, Lili, Wei, Shuang, Wang, Weimin, Sun, Yuqing, Zhao, Ende, Vatan, Linda, Szeliga, Wojciech, Kotarski, Jan, Tarkowski, Rafał, Dou, Yali, Cho, Kathleen, Hensley-Alford, Sharon, Munkarah, Adnan, Liu, Rebecca, Zou, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779053/ https://www.ncbi.nlm.nih.gov/pubmed/26503055 http://dx.doi.org/10.1038/nature15520

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