HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions ag...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Rachel P. J., Meintjes, Graeme, Wilkinson, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779131/
https://www.ncbi.nlm.nih.gov/pubmed/26423994
http://dx.doi.org/10.1007/s00281-015-0532-2
_version_ 1782419584037421056
author Lai, Rachel P. J.
Meintjes, Graeme
Wilkinson, Robert J.
author_facet Lai, Rachel P. J.
Meintjes, Graeme
Wilkinson, Robert J.
author_sort Lai, Rachel P. J.
collection PubMed
description Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
format Online
Article
Text
id pubmed-4779131
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-47791312016-03-19 HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome Lai, Rachel P. J. Meintjes, Graeme Wilkinson, Robert J. Semin Immunopathol Review Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis. Springer Berlin Heidelberg 2015-09-30 2016 /pmc/articles/PMC4779131/ /pubmed/26423994 http://dx.doi.org/10.1007/s00281-015-0532-2 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Lai, Rachel P. J.
Meintjes, Graeme
Wilkinson, Robert J.
HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title_full HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title_fullStr HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title_full_unstemmed HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title_short HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
title_sort hiv-1 tuberculosis-associated immune reconstitution inflammatory syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779131/
https://www.ncbi.nlm.nih.gov/pubmed/26423994
http://dx.doi.org/10.1007/s00281-015-0532-2
work_keys_str_mv AT lairachelpj hiv1tuberculosisassociatedimmunereconstitutioninflammatorysyndrome
AT meintjesgraeme hiv1tuberculosisassociatedimmunereconstitutioninflammatorysyndrome
AT wilkinsonrobertj hiv1tuberculosisassociatedimmunereconstitutioninflammatorysyndrome

Ejemplares similares